POTENT PRECLINICAL ACTIVITY OF FLT3-DIRECTED CHIMERIC ANTIGEN RECEPTOR T-CELL IMMUNOTHERAPY AGAINST FLT3- MUTANT ACUTE MYELOID LEUKEMIA AND KMT2A-REARRANGED ACUTE LYMPHOBLASTIC LEUKEMIA

Chimeric antigen receptor (CAR) T-cell immunotherapies targeting CD19 or CD22 induce remissions in the majority of patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL), although relapse due to target antigen loss or downregulation has emerged as a major clinical dilemma.Accordingly, great interest exists in developing CAR T c

Advance in the visualization of the bathymetric and geological data from charted to digital maps and models opened the possibility to analyse data within Geographic Information System (GIS) functionalities.In this paper, bathymetric and geological properties of the Adriatic Sea were analysed using the General Bathymetric Chart of the Ocean (GEBCO)

The composite technology based on friction stir processing (FSP) can enhance the strength of Al alloys while retaining the original toughness and ductility of Al alloys, thus achieving an improvement in the overall performance of the composites.Ni/Al composites were prepared in three typical Al matrixes by optimized FSP, and the effect of in Jeans

Over the last two decades, the insects-as-food-and-feed industry has rapidly emerged.Its growth is largely because insects require substantially less resources (water, food, and energy) to produce than traditional sources of animal protein, making it a sustainable alternative food option.As this industry continues to grow, veterinarians will likely

Abstract Background Pathogens tolerate stress conditions that include low pH, oxidative stress, high salt and high temperature in order to survive inside and outside their hosts.Lipopolysaccharide (LPS), which forms the outer-leaflet of the outer membrane in Gram-negative bacteria, acts as a permeability barrier.The lipid A moiety of LPS anchors it